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Synthesis of 2-[4-(4-Chlorophenyl)piperazin-1-yl]-2-methylpropanoic Acid...
Share: 2-[4-(4-Chlorophenyl)piperazin-1-yl]-2-methylpropanoic Acid Ethyl Ester 1-Piperazineacetic acid, 4-(4-chlorophenyl)-α,α-dimethyl-, ethyl ester...
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Synthesis of...
Share: Cas 1204588-48-6 MF C21 H20 N4 O4 MW 392.41 Benzenamine, 2,4-dinitro-N-[(2E,4E)-4-phenyl-5-(1-pyrrolidinyl)-2,4-pentadien-1-ylidene]-, [N(E)]-...
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5-(2-(3-Oxopiperazin-1-yl) propyl)-5,6-dihydropteridin-7(8H)-one
Share: COSY PREDICT 1H NMR PREDICT 1H NMR (DMSO-d6, 400 MHz): δH 0.95 (3H, d, H4), 3.09–3.23 (2H, m, H2), 3.29–3.49 (5H, m, H14, H11, H3), 3.94–4.04...
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Efficient Transposition of the Sandmeyer Reaction from Batch to Continuous...
Share: The transposition of Sandmeyer chlorination from a batch to a safe continuous-flow process was investigated. Our initial approach was to develop a cascade method using flow chemistry which...
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(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol , Furofuranol
Share: CAS : 156928-09-5 Molecular Formula: C6H10O3 Molecular Weight: 130.144 Furo[2,3-b]furan-3-ol, hexahydro-, [3R-(3α,3aβ,6aβ)]- (3R,3aS,6aR)-Hexahydrofuro[2,3-b]furan-3-ol...
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GMP’s for Early Stage Development of new Drug substances and products
Share: GMP’s for Early Stage Development of New Drug substances and products The question of how Good Manufacturing Practice (GMP) guidelines should be applied during early stages of development...
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4-(2-Hydroxyethyl)-1,3-dihydro-2H-indol-2-one
Share: 13C NMR (DMSO-d6, 100 MHz): δ = 35.2, 36.8, 61.5, 107.4, 122.5, 125.4, 127.8, 136.1, 143.8, 176.9; 1H NMR 1H NMR (DMSO-d6, 400 MHz): δ = 2.64 (t, J = 6.8 Hz, 2H), 3.44 (s, 2H), 3.59 (q, J =...
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Overcoming barriers to green chemistry in the pharmaceutical industry – the...
Share: Scheme 1. Pfizer’s Commercial Synthesis of sildenafil citrate (Viagra™) “Green chemistry” refers to the promotion of safe, sustainable, and waste-minimizing chemical processes. The...
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Methyl (Z)-11-[(3-Hydroxy)propylidene]-6,11-dihydrobenz[b,e]oxepin-2-acetate
Share: E/Z WO2014147647 White solid; Ή NMR (200 MHz, CDC13 + CC14): δ 2.38-2.49 ( m,0.8H, E- Form), 2.63-2.73 ( m,1.2H, Z-Form), 3.53 (s, 2H), 3.68 (s, 3H), 3.75 (m, 0.8H, E-Form), 3.81 (t, J=6.3 Hz,...
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Crystallization and relaxation dynamics of amorphous loratadine under...
Share: CrystEngComm, 2017, 19,335-345 DOI: 10.1039/C6CE01645F, Paper Ruimiao Chang, Qiang Fu, Yong Li, Mingchan Wang, Wei Du, Chun Chang, Aiguo Zeng In this paper, four amorphous samples of loratadine...
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Amtolmetin guacil, амтолметин гуацил , أمتولمتين غواسيل , 呱氨托美丁
Share: Amtolmetin guacil, ST-679, MED-15, Eufans CAS 87344-06-7 UNII: 323A00CRO9, Molecular Formula, C24-H24-N2-O5, Molecular Weight, 420.463, 2-Methoxyphenyl...
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An Improved Process for Pioglitazone and Its Pharmaceutically Acceptable Salt
Share: Improved synthetic approach: route A (feasibility) and B (after optimization) Rakeshwar Bandichhor Ph.D. FRSC, CChem, SSWB,BB,MB Director at Dr. Reddy’s Laboratories, Vice-Chair, ACS-India...
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Telcagepant Revisited
Share: Telcagepant, MK-0974 Molecular FormulaC26H27F5N6O3 Average mass566.523 Da 1-piperidinecarboxamide,...
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One-Pot Reductive Cyclisations of Nitroanilines to Imidazoles
Share: Hana and co-workers ( Synlett 2010, 18, 2759−2764) from Genentech have developed a single-step procedure for conversion of 2-nitro aromatic amines to benzimidazoles. Addition of ammonium...
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1-Bromo-4-fluoro-2-((2-iodobenzyl)oxy)benzene
Share: 1-Bromo-4-fluoro-2-((2-iodobenzyl)oxy)benzene CAS 1161931-51-6 Mp 89.8–92.3 °C. IR (neat, ATR): 3072 (w), 1482 (s), 1451 (s), 1294 (s), 1294 (s) cm–1. 1H NMR (399 MHz, DMSO-d6) δ 5.12 (s, 2H),...
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Dimethyl 4,4′-(Benzylazanediyl)(2E,2′E)-bis(but-2-enoate)
Share: Dimethyl 4,4′-(Benzylazanediyl)(2E,2′E)-bis(but-2-enoate) IR (CHCl3): ν = 758, 1215, 1278, 1437, 1660, 1720, 2806, 2953, 3020, 3421 cm–1; 13C NMR (CDCl3, 100 MHz) δ: 51.53, 53.42, 58.37,...
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2,2′-(1-(tert-Butoxycarbonyl)pyrrolidine-3,4-diyl)diacetic Acid
Share: 2,2′-(1-(tert-Butoxycarbonyl)pyrrolidine-3,4-diyl)diacetic Acid 2,2′-(1-(tert-Butoxycarbonyl)pyrrolidine-3,4-diyl)diacetic Acid as a white solid. Mp: 162–163 °C, % purity: 94.09% (HPLC); 1H...
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tert-Butyl 3a,4,7,7a-Tetrahydro-1H-isoindole-2(3H)-carboxylate
Share: tert-Butyl 3a,4,7,7a-Tetrahydro-1H-isoindole-2(3H)-carboxylate tert-Butyl 3a,4,7,7a-Tetrahydro-1H-isoindole-2(3H)-carboxylate as a brown oil. % Purity: 93.72% (GC); 1H NMR (CDCl3, 400 MHz) δ:...
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tert-butyl(3aR,6aS)-5-oxohexahydrocyclopenta[c]pyrrole-2(1H)-carboxylate
Share: tert-butyl(3aR,6aS)-5-oxohexahydrocyclopenta[c]pyrrole-2(1H)-carboxylate tert-Butyl (3aR,6aS)-5-Oxohexahydrocyclopenta[c]pyrrole-2(1H)-carboxylate (1) pure compound 1 (1.051 kg, 67%) as a...
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Award for me, 100 Most Impactful Health care Leaders, Global listing
Share: At award function for my award “100 Most Impactful Health care Leaders Global listing”, conferred on me at Taj lands end, Mumbai, India on 14 Feb 2014 by World Health Wellness congress and awards
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