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Continuous-Flow Process for the Synthesis of m-Nitrothioanisole
Share: A continuous-flow process for the preparation of m-nitrothioanisole has been set up. The starting material m-nitroaniline was diazotized to give diazonium chloride, followed by azo-coupling with...
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GDC-0084
Share: GDC-0084 CAS#: 1382979-44-3 Chemical Formula: C18H22N8O2 Exact Mass: 382.1866 Synonym: RG7666; RG-7666; RG 7666; GDC-0084; GDC0084; GDC 0084. IUPAC/Chemical Name:...
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Curis and Aurigene’s CA 4948, AU 4948
Share: Example 13 WO2015104688 6-(6-aminopyridin-3-yl)-N-(2-morpholin-4-yl-1,3-benzothiazol-6-yl)pyridine-2-carboxamide Molecular Formula: C22H20N6O2S Molecular Weight: 432.4982 g/mol PROBABLE...
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Curis and Aurigene’s AUPM 170, CA 170
Share: 1,2,4-oxadiazole and 1 ,2,4-thiadiazole compounds of formula (I): ONE EXAMPLE OR 1,3,4-oxadiazole and 1 ,3,4-thiadiazole compounds of formula (I): EXAMPLES PREDICTED AUPM 170, CA 170,...
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ND 2158
Share: (2S)-2-hydroxy-3-[(3R)-12-{[(1r,4r)-4-(morpholin-4-yl)cyclohexyl]oxy}-7-thia-9,11-diazatricyclo[6.4.0.0²,⁶]dodeca-1(12),2(6),8,10-tetraen-3-yl]propanamide...
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ND 2110
Share: ND -2110 Molecular Formula: C21H28N4O3S Molecular Weight: 416.53702 g/mol...
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CN-128 for the treatment of thelassemia and iron overload
Share: CN-128 (R)-3-Hydroxy-1-(1-hydroxy-3-benzyl propyl-2-)2-methyl pyridine-4(1H)-one IND Filing CN-128 is potentially for the treatment of thelassemia and iron overload. Zhejiang University, 浙江大学...
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Debiopharm and Aurigene dual c-src / jak inhibitors
Share: Debio 1142 Jak2 tyrosine kinase inhibitor; Src tyrosine kinase inhibitor...
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PF-05387552
Share: PF-05387552 IRAK4 CAS 1604034-71-0 C25 H27 N5 O2 11H-Indolo[3,2-c]quinoline-9-carbonitrile, 2-methoxy-3-[3-(4-methyl-1-piperazinyl)propoxy]-...
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FDA approves new drug Venclexta (venetoclax) for chronic lymphocytic leukemia...
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Etamicastat
Share: Etamicastat HCl salt CAS: 677773-32-9 (HCl salt) CAS 760173-05-5 (free base). Chemical Formula: C14H16ClF2N3OS Molecular Weight: 347.8088 Synonym: BIA 5-453; BIA5-453; BIA-5-453; Etamicastat...
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Zamicastat
Share: CAS 1080028-80-3 BASE 1383828-47-4 OF HCL SALT C21 H21 F2 N3 O S BASE 2H-Imidazole-2-thione,...
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AMG 337
Share:. PIC CREDIT.BETHANY HALFORD Name: AMG-337(AMG337; AMG 337) Cas 1173699-31-4 Formula: C23H22FN7O3 M.Wt: 463.46 Chemical Name:...
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INCB24360 (epacadostat)
Share: Epacadostat (Z)-N-(3-bromo-4-fluorophenyl)-N’-hydroxy-4-[2-(sulfamoylamino)ethylamino]-1,2,5-oxadiazole-3-carboxamidine 1,2,5-Oxadiazole-3-carboximidamide,...
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PF-06260414
Share: PF-06260414 CAS: 1612755-71-1 Chemical Formula: C14H14N4O2S Exact Mass: 302.0837 PF-06260414; PF 06260414; PF06260414; PF6260414; PF-6260414; PF 6260414. IUPAC/Chemical Name:...
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ND 0126
Share: ND 0126 CAS 1240322-54-6 Molecular Formula: C29H25F3N6O3 Molecular Weight: 562.54241 g/mol methyl...
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PF 14
Share: PF 14 Molecular Formula: C14H14N4O2S Molecular Weight: 302.35156 g/mol 6-[(4R)-4-methyl-1,1-dioxo-1,2,6-thiadiazinan-2-yl]isoquinoline-1-carbonitrile 1612755-71-1 CAS The androgen receptor...
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Regulatory Approval Pathways: EU vs US
Share: Regulatory Approval Pathways: EU vs US Drug Authorization Procedures in the EU Sponsors have several options when seeking market approval for a new drug in Europe: a national authorization...
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Enasidenib (AG-221)
Share: Enasidenib (AG-221) 1446502-11-9 Chemical Formula: C19H17F6N7O Exact Mass: 473.13988 AG-221; AG 221; AG221; CC-90007; CC 90007; CC90007; Enasidenib IUPAC/Chemical Name:...
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Plecanatide 普卡那肽 ليكاناتيد плеканатид
Share: PLECANATIDE; UNII-7IK8Z952OK; (3-Glutamic acid(D>E))human uroguanylin (UGN); 467426-54-6; Molecular Formula: C65H104N18O26S4 Molecular Weight: 1681.88626 g/mol IUPAC Condensed...
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