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Oliceridine
Share: Oliceridine N-[(3-methoxythiophen-2-yl)methyl]-2-[(9R)-9-(pyridin-2-yl)-6-oxaspiro[4.5]decan-9-yl]ethan-1-amine [(3-Methoxythiophen-2-yl)methyl]({2-[(9R)-9-(pyridin-2-yl)-6-oxaspiro[4.5]decan-9-...
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Marksans Pharma gets FDA nod for its ANDA for metformin hydrochloride...
Share: FDA OK for India’s Marksans Pharma Generic Version of Type 2 Diabetes Drug Read at FDA OK for India’s Marksans Pharma Generic Version of Type 2 Diabetes Drug SEE ALSO Diabetes Drug: Latest...
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Processes for Constructing Homogeneous Antibody Drug Conjugates
Share: Antibody drug conjugates (ADCs) are synthesized by conjugating a cytotoxic drug or “payload” to a monoclonal antibody. The payloads are conjugated using amino or sulfhydryl specific linkers that...
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Sun Pharma and Merck & Co. Inc. Enter into Licensing Agreement for Tildrakizumab
Share: Tildrakizumab (MK-3222) Company Merck & Co. Inc. Description Anti-IL-23 antibody Molecular Target Interleukin-23 (IL-23) Mechanism of Action Antibody Therapeutic Modality Biologic: Antibody...
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A New Antibiotic...
Share: (E)-3-(3-Carboxyphenyl)-2-(4-ethynylstyryl)quinazolin-4(3H)-one (E)-3-(2-(4-Cyanostyryl)-4-Oxoquinazolin-3(4h)-Yl)benzoic Acid; 1624273-22-8 CAS NA SALT 1624273-21-7 CAS INNOVATORS University...
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CADROFLOXACIN
Share: Cadrofloxacin , CS 940 3-Quinolinecarboxylic acid, 1-cyclopropyl-8-(difluoromethoxy)-6-fluoro-1,4-dihydro-7-[(3S)-3-methyl-1-piperazinyl]-4-oxo-, hydrochloride (1:1) UNII-1YOQ7J9ACY;...
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Nolatrexed Dihydrochloride
Share: Nolatrexed NDA Filed in china A thymidylate synthase inhibitor potentially for the treatment of hepatocellular carcinoma and nasopharyngeal cancer. AG-337 CAS No. 147149-76-6 (free) free form...
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Arbaclofen
Share: Arbaclofen placarbil (3R)-3-(4-chlorophenyl)-4-[[(1S)-2-methyl-1-(2-methylpropanoyloxy)propoxy]carbonylamino]butanoic acid NDA filed A GABA (B) receptor agonist potentially for the treatment of...
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Ixorine, a New Cyclopeptide Alkaloid from the Branches of Ixora brevifolia
Share: Figure 2 Selected key HMBC (1H 13C) and NOESY (1H 1H) correlations for ixorine (1). Figure 1 Structures of compounds 1–4 isolated from the branches of I. brevifolia. Ixorine (1) HRESIMS m/z,...
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Lupin to co-market Novartis’ asthma drug in India
Share: Lupin to co-market Novartis’ asthma drug in India BS B2B Bureau | Mumbai April 12, 2016 Last Updated at 10:27 IST Novartis Healthcare will continue to market Sequadra...
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Multibiphenyl A, New biphenyls from Garcinia multiflora.
Share: Figure 2 Selected HMBC (H→C) and 1H-1H correlation spectroscopy (COSY) (–) correlations of 1. Compound 1 was obtained as a pale yellow gum. The molecular formula was determined to be C20H22O6...
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Buthionine Sulphoximine
Share: Buthionine Sulphoximine NDA Filed in china A gamma-glutamylcysteine synthetase inhibitor potentially for the treatment of solid tumors. NSC-326231; BSO CAS No. 5072-26-4 BUTHIONINE SULFOXIMINE;...
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Dihydrobenzofuran Neolignans
Share: Figure 1 Structures of dihydrobenzofuran neolignans 2a and 2b. Scheme 1 (i) Ag2O, (CH3)2CO:C6H6 3:5, r.t., 20 h (2a: 36% yield; 2b: 43% yield). Figure 3 Main nuclear Overhauser effect (NOE)...
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Teslaphoresis of Carbon Nanotubes
Share: This paper introduces Teslaphoresis, the directed motion and self-assembly of matter by a Tesla coil, and studies this electrokinetic phenomenon using single-walled carbon nanotubes (CNTs)....
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Solvates, Salts, and Cocrystals: A Proposal for a Feasible Classification System
Share: The design of pharmaceutical cocrystals has initiated widespread debate on the classification of cocrystals. Current attempts to classify multicomponent crystals suffer from ambiguity, which has...
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Optimization, Production, and Characterization of a...
Share: We have synthesized and characterized a novel phosphorothioate CpG oligodeoxynucleotide (CpG ODN)-Ficoll conjugated nanoparticulate adjuvant, termed DV230-Ficoll. This adjuvant was constructed...
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BMS-520, a Potent and Selective Isoxazole-Containing S1P1 Receptor Agonist
Share: BMS-520 CAS: 1236188-38-7 MF: C23H17F3N4O4 MW: 470.1202 Synonym: BMS-520; BMS 520; BMS520. INNOVATOR Bristol-Myers Squibb Company INVENTORS Scott Hunter Watterson, Alaric J. Dyckman,William J....
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Letermovir, AIC 246
Share: Letermovir, MK 8828, AIC 246 2-[(4S)-8-fluoro-2-[4-(3-methoxyphenyl)piperazin-1-yl]-3-[2-methoxy-5-(trifluoromethyl)phenyl]-4H-quinazolin-4-yl]acetic acid CAS 917389-32-3 Letermovir;...
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Ethyl 1-(7-chloroquinolin-4-yl)-5-methyl-1H-1,2,3-triazole-4-carboxylate
Share: Scheme 1 General scheme of the reaction. Scheme 2 General procedure for the synthesis of 7-chloroquinoline-1,2,3-triazoyl carboxylates To a solution of 4-azido-7-chloroquinoline 1 (0.3...
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ICH Q3D Implementation Working Group (IWG)—Training Modules
Share: ICH Q3D Implementation Working Group (IWG)—Training Modules ICH Q3D is a complex guideline. The overall requirement in terms of control is clear—there are defined limits for some 24 elements,...
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